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Galanin (1-13)-Substance P (5-11) amide;GALANTIDE| Galantide
Galanin (1-13)-Substance P (5-11) amide;GALANTIDE| Galantide
CAS No. 138579-66-5
Galanin (1-13)-Substance P (5-11) amide;GALANTIDE| Galantide( ——— )
Catalog No. M40200 CAS No. 138579-66-5
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGalanin (1-13)-Substance P (5-11) amide;GALANTIDE| Galantide
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NoteResearch use only, not for human use.
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Brief DescriptionGalantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM).
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DescriptionGalantide is a reversible and non-specific antagonist of galanin receptor.
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In VitroGalantide do not activate the K+ conductance but produces a concentration-dependent antagonism (IC50=4 nM) of the galanin-induced increase in K+ conductance. Galantide acts like galanin and inhibits the voltage-dependent Ba2+ current (IBa). The inhibition of IBa also is concentration dependent (IC50=16 nM) and the maximum inhibition produced by galantide is approximately 40%.
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In VivoIntracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area———
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Indication———
Chemical Information
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CAS Number138579-66-5
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Formula Weight2199.53
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Molecular FormulaC104H151N25O26S
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Langel U, et al. Design of chimeric peptide ligands to galanin receptors and substance P receptors. Int J Pept Protein Res. 1992;39(6):516-522.?
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