Big Endothelin-1 (1-31) (human, bovine)

Research use only, not for human use.

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase.

Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase.

Cell Proliferation Assay Cell Line:Human mesangial cells Concentration:100 pM-100 nM Incubation Time:24 h Result:Caused an increase in [3H]-thymidine incorporation into the cells in a concentration-dependent manner.Western Blot Analysis Cell Line:Human mesangial cells Concentration:100 nM Incubation Time:0, 5, 10, 15 and 30 min Result:ERK activities rapidly increased 2.45-fold at 5 min and peaked at 10 min. The activities of both ERKs rapidly declined, returning to the baseline control value 30 min after stimulation.

Animal Model:ICR mice, Streptozocin -induced diabetic model Dosage:100 nM Administration:In the organ bath, single dose Result:In the 1-week control (but not diabetic) group, induced contraction and the contractile response was significantly greater in female mice than in male mice, and there was no significant difference in either male or female mice between the age-matched controls and the diabetic mice. In the 8-weeks group, the contraction was or tended to be increased compared with the corresponding 1-week group in all mice. Although in male mice this contraction was not different between control and diabetic groups, it was significantly greater in diabetic female mice than in the control female mice and in female diabetic mice than in male diabetic mice. The contraction was inhibited by ETA receptor inhibitor.

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Others

Other Targets

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133972-52-8

3628.16

C162H236N38O47S5

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years