(D-Arg2,Lys4)-Dermorphin (1-4) amide

Research use only, not for human use.

DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects.

DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects.

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Animal Model:Male Sprague-Dawley rats (300–350 g)Dosage:0.24, 0.7 and 7 nmol/rat Administration:Intrathecal injection, once Result:Showed antinociceptive effects with an ED50 of 237 pmol/rat in the rat tail-flick test. Inhibited the uptake of NE in spinal cord synaptosomes in a dose-dependent manner. Had no effect on 5-HT uptake. Produced depression in minute ventilation.Animal Model:Male Long-Evans rats, weighing 200-225 g Dosage:0, 0.1 and 1.0 μg/side, 0.5 μL Administration: Lateral cerebral ventricle injection, once Result:Elicited a significant biphasic effect with an initial suppression, an intermediate marked inhibition, followed by significant activation for horizontal movement time, rearing time, and stereotypy time.

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Others

Other Targets

μ Opioid Receptor/MOR: 1.69 nM (Ki), κ Opioid Receptor/KOR: 4230 nM (Ki), δ Opioid Receptor/DOR: 19200 nM (Ki)

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118476-85-0

611.75

C30H45N9O5

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years