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Home - Products - Others - Other Targets - (D-Arg2,Lys4)-Dermorphin (1-4) amide

(D-Arg2,Lys4)-Dermorphin (1-4) amide

CAS No. 118476-85-0

(D-Arg2,Lys4)-Dermorphin (1-4) amide( ——— )

Catalog No. M40130 CAS No. 118476-85-0

DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    (D-Arg2,Lys4)-Dermorphin (1-4) amide
  • Note
    Research use only, not for human use.
  • Brief Description
    DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects.
  • Description
    DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects.
  • In Vitro
    ———
  • In Vivo
    Animal Model:Male Sprague-Dawley rats (300–350 g)Dosage:0.24, 0.7 and 7 nmol/rat Administration:Intrathecal injection, once Result:Showed antinociceptive effects with an ED50 of 237 pmol/rat in the rat tail-flick test. Inhibited the uptake of NE in spinal cord synaptosomes in a dose-dependent manner. Had no effect on 5-HT uptake. Produced depression in minute ventilation.Animal Model:Male Long-Evans rats, weighing 200-225 g Dosage:0, 0.1 and 1.0 μg/side, 0.5 μL Administration: Lateral cerebral ventricle injection, once Result:Elicited a significant biphasic effect with an initial suppression, an intermediate marked inhibition, followed by significant activation for horizontal movement time, rearing time, and stereotypy time.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    μ Opioid Receptor/MOR: 1.69 nM (Ki), κ Opioid Receptor/KOR: 4230 nM (Ki), δ Opioid Receptor/DOR: 19200 nM (Ki)
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    118476-85-0
  • Formula Weight
    611.75
  • Molecular Formula
    C30H45N9O5
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shimoyama M, et al. Antinociceptive and respiratory effects of intrathecal H-Tyr-D-Arg-Phe-Lys-NH2 (DALDA) and Dmt1 DALDA. Journal of Pharmacology and Experimental Therapeutics, 2001, 297(1): 364-371.?
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