Osteocalcin (45-49) (human)( ——— )

Catalog No. M40062 CAS No. 85679-70-5

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Product Name

Osteocalcin (45-49) (human)
Note

Research use only, not for human use.
Brief Description

Bone Gla Protein (45-49) is the 45-49 fragment of gamma-carboxyglutamic acid (GLA)-containing protein from bone (BGP, osteocalcin), which has chemotactic activity in vitro for a number of cells which are found adjacent to endosteal bone surfaces in vivo.
Description

Bone Gla Protein (45-49) is the 45-49 fragment of gamma-carboxyglutamic acid (GLA)-containing protein from bone (BGP, osteocalcin), which has chemotactic activity in vitro for a number of cells which are found adjacent to endosteal bone surfaces in vivo.
In Vitro

Bovine bone Gla protein (BGP) (1 nM-10 μM) exerts chemotactic activity of (0.1 and 1 μM) cultured human breast cancer cells (MDA-MB-231 cells), (1 nM-1 μM) human peripheral blood monocytes, and (1-10 μM) rat osteosarcoma cells with osteoblast-like characteristics.
In Vivo

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Indication

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1. Mundy GR, et al. Chemotactic activity of the gamma-carboxyglutamic acid containing protein in bone. Calcif Tissue Int. 1983;35(2):164-8. ?

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