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Kisspeptin-13 (human)

CAS No. 374675-18-0

Kisspeptin-13 (human)( ——— )

Catalog No. M39986 CAS No. 374675-18-0

Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Kisspeptin-13 (human)
  • Note
    Research use only, not for human use.
  • Brief Description
    Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research.
  • Description
    Kisspeptin 13 is a GPR54 and GnRH receptor activator, an endogenous active isoform. Kisspeptin 13 enhances memory and can be used in Alzheimer's disease research.
  • In Vitro
    ———
  • In Vivo
    Kisspeptin 13 (intracerebroventricular administration; 2 μg/side; once) treatment improves object recognition memory impairment induced by Aβ through activation of GPR54 and GnRH receptor.Animal Model:Male Swiss mice with memory impairment induced by A-beta Dosage:2 μg/side Administration:Intracerebroventricular administration; 2 μg/side; once Result:Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    374675-18-0
  • Formula Weight
    1626.85
  • Molecular Formula
    C78H107N21O18
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jiang JH, et al. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 Sep;123:187-95.?
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