Potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.

Azetirelin, as a TRH analog, has a more potent effect than TRH on the central nervous system.

Eltoprazine dihydrochloride is a drug that had previously been developed for aggression has recently been investigated for L-DOPA-induced dyskinesia in animal models of Parkinson′s disease (PD) and in dyskinetic PD patients.?