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Apelin-12 (human, bovine, mouse, rat)
CAS No. 229961-08-4
Apelin-12 (human, bovine, mouse, rat)( ——— )
Catalog No. M39852 CAS No. 229961-08-4
Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 10MG | 743 | In Stock |
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Biological Information
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Product NameApelin-12 (human, bovine, mouse, rat)
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NoteResearch use only, not for human use.
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Brief DescriptionApelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect.
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DescriptionApelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor.
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In VitroApelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse.Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents.Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorHIV-1
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Research Area———
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Indication———
Chemical Information
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CAS Number229961-08-4
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Formula Weight1422.72
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Molecular FormulaC64H103N21O14S1
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Purity>98% (HPLC)
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Solubility?H2O : ≥ 100 mg/mL (70.29 mM)
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203.?
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