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Simvastatin Hydroxy Acid Sodium Salt
CAS No. 101314-97-0
Simvastatin Hydroxy Acid Sodium Salt( ——— )
Catalog No. M39577 CAS No. 101314-97-0
Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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Biological Information
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Product NameSimvastatin Hydroxy Acid Sodium Salt
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NoteResearch use only, not for human use.
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Brief DescriptionSimvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
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DescriptionSimvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor.
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In VitroSimvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells.Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells.Western Blot Analysis Cell Line:hCM and HEK293 (transfected with OATP3A1)Concentration:0.1, 1, 10 and 20 μM Incubation Time:24 h Result:Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorHMG-CoA reductase, Reactive oxygen species
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Research Area———
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Indication———
Chemical Information
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CAS Number101314-97-0
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Formula Weight458.56
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Molecular FormulaC25H39NaO6
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272.?
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