Isoquinoline

Research use only, not for human use.

Isoquinoline is an analog of pyridine. Isoquinoline-based alkaloids, such as p-tolyl bisisoquinoline, phthaloyl isoquinoline, and naphthyl isoquinoline, exhibit anticancer activity.Berberine, an isoquinoline alkaloid, exerts anti-inflammatory effects in diabetic mice by downregulating the gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines.Additionally, some isoquinoline-based compounds also possess antidepressant, antibacterial, antimalarial, and anti-HIV activities.

Isoquinoline is an analog of pyridine. Isoquinoline structural-based alkaloids, such as tropoloisoquinoline, phthalideisoquinoline, and naphthylisoquinoline has anti-cancer activities.

Western Blot Analysis Cell Line:Hippocampal neurons (rat)Concentration:20-80 μM Incubation Time:14 days Result:Led that the Bax/Bcl-2 ratio was altered, reduced expression of apoptotic marker Caspase-3.

Animal Model:Chronic unpredictable mild stress (CUMS)-induced depressive-like male adult Swiss mice model (25–35 g) Dosage:0.1 and 1 mg/kg Administration:Intragastric administration (i.g), once daily for 35 days Result:Effectively abolished depressive-like behavior in CUMS-exposed mice, improving self-care and motivation in the splash test and reducing immobility time in the TST and modified FST.Did not affect spontaneous locomotion, ruling out psychostimulant interference.Prevented the CUMS-induced increase in NF-κB and pro-inflammatory cytokines (TNF-α, INF-γ, IL-1, IL-6) in the prefrontal cortex and serum, while restoring IL-10 levels.FDPI prevented the CUMS-induced elevation of corticosterone and ACTH, counteracting the increase in adrenal weight, suggesting regulation of HPA axis hyperactivity.Prevented the CUMS-induced increase in 5-HT uptake in synaptosomes, indicating modulation of serotonergic neurotransmission.Counteracted the CUMS-induced increase in pro-BDNF and decrease in TrkB in the prefrontal cortex, suggesting a role in neuroplasticity restoration.Exerted antidepressant-like effects at lower doses than paroxetine, but its superiority over paroxetine could not be confirmed due to different administration routes (intragastric vs. intraperitoneal).Demonstrated potential as a multi-target antidepressant, with effects mediated by anti-inflammatory actions, HPA axis modulation, serotonin system regulation, and neurotrophic signaling pathways. Further studies on chronic administration and side effects are needed.

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Others

Other Targets

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119-65-3

129.16

C9H7N

>98% (HPLC)

DMSO : 100 mg/mL (774.22 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years