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Swainsonine

CAS No. 72741-87-8

Swainsonine( ——— )

Catalog No. M39478 CAS No. 72741-87-8

Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Swainsonine
  • Note
    Research use only, not for human use.
  • Brief Description
    Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.
  • Description
    Swainsonine is an alkaloid isolated from Astragalus, acts as an inhibitor of α-mannosidase, with anti-tumor activity.
  • In Vitro
    Cell Viability Assay Cell Line:U251, LN444 cells Concentration:0, 10, 20, 30, 40 μM Incubation Time:12 h Result:Inhibited cell viability in a dose-dependent manner, and shows no cytotoxicity in normal brain cells.Cell Cycle Analysis Cell Line:U251 cells Concentration:30 μM Incubation Time:12 h Result:Induced cell cycle arrest at G2/M phase.Apoptosis Analysis Cell Line:U251 cells Concentration:30 μM Incubation Time:12 h Result:Induced apoptosis with the cleaved-Caspase-3 and cleaved-Caspase-9 expression were obviously increased.
  • In Vivo
    Animal Model:Eighty-seven sixty-day-old male C57BL/6 mice Dosage:1 mg/kg (cisplatin; 0.25 mg/kg, i.p., every other day for 10 days) Administration:I.p.; twice daily for ten days Result:Showed a significant reduction in ascites volume of 63.5% was observed in mice and a significant reduction in the percentage of cells in the G0/G1, S and G2 phases.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    α-mannosidase
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    72741-87-8
  • Formula Weight
    173.21
  • Molecular Formula
    C8H15NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 10 mg/mL (57.73 mM; ultraphonic; ) Ethanol : 10 mg/mL (57.73 mM; ultraphonic)
  • SMILES
    OC1CN2CCCC(O)C2C1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dorling PR, et al. Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. Biochem J. 1980 Nov 1;191(2):649-51.?
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