LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).

Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.

1-Methylhydantoin is a small molecular weight polar substance the product of degradation of creatinine by bacteria. In mammals the metabolism of 1-methylhydantoin occurs via 5-hydroxy-1-methylhydantoin. In a reported human case 1-Methylhydantoin was found as an unexpected metabolite of the intelligence-affecting substance dupracetam.