TMX-4100( ——— )

Catalog No. M39457 CAS No. 2367619-63-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TMX-4100
Note

Research use only, not for human use.
Brief Description

TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma.
Description

TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma.
In Vitro

Western Blot Analysis Cell Line:MOLT4 cells Concentration:1 μM Incubation Time:4 hours Result:Showed a high degradation preference for PDE6D.Western Blot Analysis Cell Line:MOLT4, Jurkat, and MM.1S cells Concentration:0 nM, 40 nM, 200 nM, 1 μM;Incubation Time:4 hours Result:Showed a high degradation preference for PDE6D with the DC50 value less than 200 nM.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

PDE6D
Research Area

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Indication

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1. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.?

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