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Ipivivint
CAS No. 1481617-15-5
Ipivivint( ——— )
Catalog No. M39455 CAS No. 1481617-15-5
Ipivivint (Compound 38) is an orally active and potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 600 | In Stock |
|
| 25MG | 1554 | In Stock |
|
| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIpivivint
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NoteResearch use only, not for human use.
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Brief DescriptionIpivivint (Compound 38) is an orally active and potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM).
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DescriptionIpivivint (compound 38) is a potent CDC-like kinase (CLK) inhibitor with EC50s of 1 nM, 7 nM for CLK2 and CLK3, respectively. Ipivivint inhibits Wnt pathway (EC50=13 nM).
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In VitroWestern Blot Analysis Cell Line:SW480 cells Concentration:0.01~10 μM Incubation Time:1 hourResult:Potently inhibited SRSF5/6 phosphorylation.Apoptosis Analysis Cell Line:SW480 cells Concentration:0.01~10 μM Incubation Time:0.03 μM~3 μM Result:Induced apoptosis.RT-PCR Cell Line:HEK-293T cells Concentration:0.3~3 μM Incubation Time:1 hour Result:Inhibited Wnt/β-catenin signaling induced by Wnt3a.Immunofluorescence Cell Line:SW480 cells Concentration:0.3~10 μM Incubation Time:6 hours Result:Increased nuclear speckle enlargement.
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In VivoAnimal Model:Foxn1 mice Dosage:25 mg/kg Administration:P.o.Result:Potently inhibited tumor SRSF6 phosphorylation.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorCDK2: 1 nM (EC50, CDK3: 7 nM (EC50)
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Research Area———
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Indication———
Chemical Information
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CAS Number1481617-15-5
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Formula Weight464.5
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Molecular FormulaC26H21FN8
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Purity>98% (HPLC)
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SolubilityDMSO : 3.33 mg/mL (7.17 mM; ultraphonic (<80°C); )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Betty Tam, et al. Methods of treating cancer using a clk inhibitor. WO2020006115A1.
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