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LOM612

CAS No. 2173232-79-4

LOM612( ——— )

Catalog No. M39454 CAS No. 2173232-79-4

LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LOM612
  • Note
    Research use only, not for human use.
  • Brief Description
    LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.
  • Description
    LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.
  • In Vitro
    LOM612 potently activates nuclear translocation of FOXO with an EC50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC50, 2.76 μM).
  • In Vivo
    ———
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    FOXO
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    2173232-79-4
  • Formula Weight
    258.3
  • Molecular Formula
    C13H10N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 6 mg/mL (23.23 mM; ultraphonic; )
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cautain B, et al. Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS One. 2016 Dec 9;11(12):e0167491.?
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