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LOM612
CAS No. 2173232-79-4
LOM612( ——— )
Catalog No. M39454 CAS No. 2173232-79-4
LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 302 | In Stock |
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| 2MG | 265 | In Stock |
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| 25MG | Get Quote | In Stock |
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| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLOM612
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NoteResearch use only, not for human use.
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Brief DescriptionLOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.
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DescriptionLOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.
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In VitroLOM612 potently activates nuclear translocation of FOXO with an EC50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. LOM612 is cytotoxic to HepG2 cells, with an IC50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC50, 2.76 μM).
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorFOXO
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Research Area———
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Indication———
Chemical Information
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CAS Number2173232-79-4
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Formula Weight258.3
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Molecular FormulaC13H10N2O2S
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Purity>98% (HPLC)
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SolubilityDMSO : 6 mg/mL (23.23 mM; ultraphonic; )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cautain B, et al. Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling. PLoS One. 2016 Dec 9;11(12):e0167491.?
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