MU 380

Research use only, not for human use.

MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity.

MU-380 is an effective and selective inhibitor of CHK1.

Apoptosis Analysis Cell Line:MEC-1and MEC-2?cells Concentration:400 nM Incubation Time:24 h Result:Showed accumulation in S phase as well as reduction in G2/M phase, greatly reduced rate of DNA synthesis, and marked induction of apoptosis (PARP protein cleavage).Western Blot Analysis Cell Line:Chronic lymphocytic leukemia cells Concentration:100 nM or 200 nM Incubation Time:24 h Result:Potently blocked CHK1 activation while enhancing ATR kinase signaling to CHK1 (pS317 and pS345), and resulted in decreased levels of total CDC25A and CDC25C, pY15 CDK1, cyclin B1 and cyclin E1.

Animal Model:NOD-scid?IL2Rγnull?mice Dosage:20 mg/kg Administration:In 20% aqueous Kolliphor solution, every three days from day 14 to day 28 Result:Significantly inhibit the growth of tumors and gradually reduce their volume, with an average reduction of about 61%.

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Others

Other Targets

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2109805-78-7

430.23

C15H15BrF3N7

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years