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RB-3

CAS No. 2396639-11-3

RB-3( ——— )

Catalog No. M39430 CAS No. 2396639-11-3

RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

RB-3
Note

Research use only, not for human use.
Brief Description

RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
Description

RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
In Vitro

Western Blot Analysis Cell Line:TEX cells.Concentration:6, 12, 25 μM.Incubation Time:8d.Result:Dose-dependently increased C/EBPα-p42 protein levels.
In Vivo

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Synonyms

———
Pathway

Others
Target

Other Targets
Recptor

Kd: 2.8 μM (RING1B-BMI1f).
Research Area

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Indication

———

Chemical Information

CAS Number

2396639-11-3
Formula Weight

417.89
Molecular Formula

C24H20ClN3O2
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL (239.30 mM; ultraphonic; )
SMILES

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Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793.?

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