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RB-3
CAS No. 2396639-11-3
RB-3( ——— )
Catalog No. M39430 CAS No. 2396639-11-3
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameRB-3
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NoteResearch use only, not for human use.
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Brief DescriptionRB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
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DescriptionRB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
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In VitroWestern Blot Analysis Cell Line:TEX cells.Concentration:6, 12, 25 μM.Incubation Time:8d.Result:Dose-dependently increased C/EBPα-p42 protein levels.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorKd: 2.8 μM (RING1B-BMI1f).
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Research Area———
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Indication———
Chemical Information
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CAS Number2396639-11-3
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Formula Weight417.89
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Molecular FormulaC24H20ClN3O2
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (239.30 mM; ultraphonic; )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793.?
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