RB-3

CAS No. 2396639-11-3

RB-3( ——— )

Catalog No. M39430 CAS No. 2396639-11-3

RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RB-3
  • Note
    Research use only, not for human use.
  • Brief Description
    RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
  • Description
    RB-3, a PRC1 inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM.
  • In Vitro
    Western Blot Analysis Cell Line:TEX cells.Concentration:6, 12, 25 μM.Incubation Time:8d.Result:Dose-dependently increased C/EBPα-p42 protein levels.
  • In Vivo
    ———
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Kd: 2.8 μM (RING1B-BMI1f).
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    2396639-11-3
  • Formula Weight
    417.89
  • Molecular Formula
    C24H20ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL (239.30 mM; ultraphonic; )
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shirish Shukla, et al. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat Chem Biol. 2021 Jul;17(7):784-793.?
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