GDC-1971( ——— )

Catalog No. M39427 CAS No. 2377352-49-1

Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor. Migoprotafib inhibits the MAPK/ERK signaling pathway, and exhibits antitumor activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	372	In Stock
5MG	345	In Stock
10MG	553	In Stock
25MG	1112	In Stock
50MG	1739	In Stock
100MG	2762	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

GDC-1971
Note

Research use only, not for human use.
Brief Description

Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor. Migoprotafib inhibits the MAPK/ERK signaling pathway, and exhibits antitumor activity.
Description

Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor.
In Vitro

Western Blot Analysis Cell Line:RIT1 Concentration:0-10 μM Incubation Time:24 h Result:Inhibited the p-ERK1/2.
In Vivo

Animal Model:RIT1 xenograft mouse models Dosage:60 mg/kg Administration:po for 28 days Result:Inhibited tumor growth.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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Chemical Information

CAS Number

2377352-49-1
Formula Weight

454.53
Molecular Formula

C25H26N8O
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL (220.01 mM; ultraphonic; )
SMILES

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Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Alexander M, et al. Shp2 phosphatase inhibitors and methods of use thereof. Patent WO2019183367A1.2. Maddalo D, et al. RIT1M90I is a driver of lung adenocarcinoma tumorigenesis and resistance to targeted therapyJ. 2024.

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