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GDC-1971

CAS No. 2377352-49-1

GDC-1971( ——— )

Catalog No. M39427 CAS No. 2377352-49-1

Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor. Migoprotafib inhibits the MAPK/ERK signaling pathway, and exhibits antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 372 In Stock
5MG 345 In Stock
10MG 553 In Stock
25MG 1112 In Stock
50MG 1739 In Stock
100MG 2762 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    GDC-1971
  • Note
    Research use only, not for human use.
  • Brief Description
    Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor. Migoprotafib inhibits the MAPK/ERK signaling pathway, and exhibits antitumor activity.
  • Description
    Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor.
  • In Vitro
    Western Blot Analysis Cell Line:RIT1 Concentration:0-10 μM Incubation Time:24 h Result:Inhibited the p-ERK1/2.
  • In Vivo
    Animal Model:RIT1 xenograft mouse models Dosage:60 mg/kg Administration:po for 28 days Result:Inhibited tumor growth.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    2377352-49-1
  • Formula Weight
    454.53
  • Molecular Formula
    C25H26N8O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL (220.01 mM; ultraphonic; )
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Alexander M, et al. Shp2 phosphatase inhibitors and methods of use thereof. Patent WO2019183367A1.2. Maddalo D, et al. RIT1M90I is a driver of lung adenocarcinoma tumorigenesis and resistance to targeted therapyJ. 2024.
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