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GDC-1971
CAS No. 2377352-49-1
GDC-1971( ——— )
Catalog No. M39427 CAS No. 2377352-49-1
Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor. Migoprotafib inhibits the MAPK/ERK signaling pathway, and exhibits antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 372 | In Stock |
|
| 5MG | 345 | In Stock |
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| 10MG | 553 | In Stock |
|
| 25MG | 1112 | In Stock |
|
| 50MG | 1739 | In Stock |
|
| 100MG | 2762 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGDC-1971
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NoteResearch use only, not for human use.
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Brief DescriptionMigoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor. Migoprotafib inhibits the MAPK/ERK signaling pathway, and exhibits antitumor activity.
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DescriptionMigoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor.
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In VitroWestern Blot Analysis Cell Line:RIT1 Concentration:0-10 μM Incubation Time:24 h Result:Inhibited the p-ERK1/2.
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In VivoAnimal Model:RIT1 xenograft mouse models Dosage:60 mg/kg Administration:po for 28 days Result:Inhibited tumor growth.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number2377352-49-1
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Formula Weight454.53
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Molecular FormulaC25H26N8O
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (220.01 mM; ultraphonic; )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Alexander M, et al. Shp2 phosphatase inhibitors and methods of use thereof. Patent WO2019183367A1.2. Maddalo D, et al. RIT1M90I is a driver of lung adenocarcinoma tumorigenesis and resistance to targeted therapyJ. 2024.
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