Crocin-4

Research use only, not for human use.

Crocin-4, a carotenoid constituent of saffron, is a potent and brain-penetrant antioxidant agent. Crocin-4 can inhibit the aggregation and the concomitant deposition of Aβ fibrils in the brain. Crocin-4 can be used for the research of Alzheimer's Disease. Crocin-4 also exhibits antitumor and anti-inflammatory activities.

Crocin-4, a carotenoid constituent of saffron, is a potent and brain-penetrant antioxidant agent. Crocin-4 can inhibit the aggregation and the concomitant deposition of Aβ fibrils in the brain.

Crocin-4 (0.1-1000 μM; 24-72 h) do not compromise cell viability of neuron-like cells.Crocin-4 (1 mM; 72 h) reduces total PSEN1, PSEN1 and PSEN2 complexes, BACE1, APP-C99 and sAPPα, while it increases PSEN1-CTF and PSEN2 in SH-SY5Y-APP cells. Crocin-4 (1 mM; 72 h) suppresses GSK3β and ERK1/2 kinases in PC12-htau cells, and significantly reduces the levels and phosphorylation of tau on the pThr231 and pSer199/Ser202 epitopes.Western Blot Analysis Cell Line:Differentiated SH-SY5Y-APP cells Concentration:1 mM Incubation Time:72 hours Result:Significantly reduced total PSEN1 by 19%, and the PSEN1 and PSEN2 complexes by 81 and 65%, while it increased PSEN1-CTF (26%) and PSEN2 (43%).The key molecules of the amyloidogenic pathway, BACE1 and APP-C99 were significantly reduced by 20 and 28%, respectively.The non-amyloidogenic pathway product sAPPα was also reduced, by 44%, while APP-C83 remained unaltered.Western Blot Analysis Cell Line:Differentiated PC12-htau cells Concentration:1 mM Incubation Time:72 hours Result:Significantly reduced total tau levels (by 32%) and tau phosphorylation (pThr231 and pSer199/Ser202-tau by 22 and 75%, respectively).Downregulates the active and inactive forms of GSK3β (total GSK3β by 34%, pSer9-GSK3β by 30%) and ERK1/2 (total ERK2 by 37%, pERK1 by 40%, pERK2 by 50%).

Crocin-4 (50 mg/kg; i.p.) is capable of crossing the Blood Brain Barrier (BBB) and build up levels in the mouse brain.

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Others

Other Targets

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55750-86-2

504.576

C27H36O9

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years