(E)-[6]-Dehydroparadol shows growth inhibition and induction of apoptosis against human cancer cells(IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively).

BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model.

PythiDC is a selective collagen prolyl 4-hydroxylase inhibitor, neither causing general toxicity nor disrupting iron homeostasis.