Isorhyncophylline and rhyncophylline can directly inhibit the contractile responses induced by several agonists in small blood vessels of rat, they also can inhibit the hypertensive effect of angiotensin Ⅱ.

Coreopsin is one of the main components from Coreopsis tinctoria Nutt. Flower(CTF). CTF has been used traditionally in China for treating hypertension and diabetes as well as reducing body weight and blood fat.

RRX-001 (RRX001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity.