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Physostigmine
CAS No. 57-47-6
Physostigmine( ——— )
Catalog No. M38998 CAS No. 57-47-6
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePhysostigmine
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NoteResearch use only, not for human use.
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Brief DescriptionPhysostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.
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DescriptionPhysostigmine is a potent and reversible inhibitor of cholinesterase. It is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE).
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In Vitro———
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In VivoPhysostigmine (Eserine; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.Physostigmine (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats. Animal Model:Heterozygous transgenic mice (Tg(+) mice)Dosage:0.03, 0.1, and 0.3 mg/kg Administration:SC; daily for 6 weeks Result:Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number57-47-6
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Formula Weight275.35
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Molecular FormulaC15H21N3O2
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Purity>98% (HPLC)
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SolubilityDMSO : 50 mg/mL (181.59 mM; ultraphonic; )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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