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Home - Products - Others - Other Targets - 1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol

1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol

CAS No. 133740-30-4

1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol( ——— )

Catalog No. M38832 CAS No. 133740-30-4

BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol
  • Note
    Research use only, not for human use.
  • Brief Description
    BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.
  • Description
    BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.
  • In Vitro
    BChE-IN-11 (compound 10) shows inhibition activity for BChE and AChE, with inhibition of 96.6 ± 1.2% and 19.1 ± 3.8% at 25 μg/mL, respectively.BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82.
  • In Vivo
    ———
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    BChE: 2.1\u2009±\u20090.3 μM (IC50), AChE
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    133740-30-4
  • Formula Weight
    346.38
  • Molecular Formula
    C22H18O4
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu Y, et al. Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors. Sci Rep. 2022 Aug 11;12(1):13649.?
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