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1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol
CAS No. 133740-30-4
1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol( ——— )
Catalog No. M38832 CAS No. 133740-30-4
BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 1554 | Get Quote |
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| 50MG | Get Quote | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name1-(4-hydroxybenzyl)-4-methoxypenanthrene-2,7-diol
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NoteResearch use only, not for human use.
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Brief DescriptionBChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.
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DescriptionBChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.
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In VitroBChE-IN-11 (compound 10) shows inhibition activity for BChE and AChE, with inhibition of 96.6 ± 1.2% and 19.1 ± 3.8% at 25 μg/mL, respectively.BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorBChE: 2.1\u2009±\u20090.3 μM (IC50), AChE
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Research Area———
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Indication———
Chemical Information
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CAS Number133740-30-4
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Formula Weight346.38
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Molecular FormulaC22H18O4
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu Y, et al. Biological evaluation, molecular modeling and dynamics simulation of phenanthrenes isolated from Bletilla striata as butyrylcholinesterase inhibitors. Sci Rep. 2022 Aug 11;12(1):13649.?
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