Licarin A b

Research use only, not for human use.

Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression.

Licarin A is a neolignan isolated from various plants.

Licarin A is found in plants such asAristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects. Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels.

———

———

Others

Other Targets

———

———

———

51020-86-1

326.39

C20H22O4

>98% (HPLC)

DMSO : ≥ 50 mg/mL (153.19 mM; ) H2O : < 0.1 mg/mL (insoluble)

O(C)C1=C2C([C@@H](C)[C@@H](O2)C3=CC(OC)=C(O)C=C3)=CC(/C=C/C)=C1

——

(-20℃)

With Ice Pack

≥ 2 years