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Acetyl Dopamine DimerIII
CAS No. 916888-49-8
Acetyl Dopamine DimerIII( ——— )
Catalog No. M38615 CAS No. 916888-49-8
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameAcetyl Dopamine DimerIII
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NoteResearch use only, not for human use.
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Brief DescriptionN-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity.
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DescriptionN-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity.
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In VitroN-Acetyldopamine dimer-2 inhibits copper-mediated, 2,2’azobis(2-amidinopropane) hydrochloride (AAPH)-mediated, and 3-morpholinosydnonimine (SIN)-1-mediated LDL oxidation with IC50 values of 1.5, 2.7 and 1.6 μM, respectively. N-Acetyldopamine dimer-2 (100 μM; 40 min) shows strong radical scavenging capacity.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently reduces the ROS level in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently and slightly decreases the NO production and iNOS protein expression in LPS-stimulated RAW264.7 cells.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) decreases the mRNA levels of IL-6, TNF-α, and COX-2 and dose-dependently inhibits secretion of IL-6, and inhibits the LPS-induced NF-κB activation in RAW264.7 cells.Western Blot Analysis Cell Line:LPS-stimulated RAW264.7 cell line Concentration:200 and 400 μM Incubation Time:2 hours Result:Slightly decreased iNOS protein expression in LPS-stimulated RAW264.7 cells.Western Blot Analysis Cell Line:LPS-stimulated RAW264.7 cell line Concentration:200 and 400 μM Incubation Time:2 hours Result:Dose-dependently decreased the mRNA levels of IL-6, TNF-α and COX-2.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorIC50: 1.5 μM (copper-mediated LDL oxidation), 2.7 μM (AAPH-mediated LDL oxidation), 1.6 μM (SIN-1-mediated LDL oxidation)
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Research Area———
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Indication———
Chemical Information
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CAS Number916888-49-8
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Formula Weight384.38
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Molecular FormulaC20H20N2O6
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu MZ, et al. Antioxidant and anti-inflammatory activities of N-acetyldopamine dimers from Periostracum Cicadae. Bioorg Med Chem. 2006 Dec 1;14(23):7826-34.?
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