Acetyl Dopamine DimerIII

Research use only, not for human use.

N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity.

N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity.

N-Acetyldopamine dimer-2 inhibits copper-mediated, 2,2’azobis(2-amidinopropane) hydrochloride (AAPH)-mediated, and 3-morpholinosydnonimine (SIN)-1-mediated LDL oxidation with IC50 values of 1.5, 2.7 and 1.6 μM, respectively. N-Acetyldopamine dimer-2 (100 μM; 40 min) shows strong radical scavenging capacity.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently reduces the ROS level in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently and slightly decreases the NO production and iNOS protein expression in LPS-stimulated RAW264.7 cells.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) decreases the mRNA levels of IL-6, TNF-α, and COX-2 and dose-dependently inhibits secretion of IL-6, and inhibits the LPS-induced NF-κB activation in RAW264.7 cells.Western Blot Analysis Cell Line:LPS-stimulated RAW264.7 cell line Concentration:200 and 400 μM Incubation Time:2 hours Result:Slightly decreased iNOS protein expression in LPS-stimulated RAW264.7 cells.Western Blot Analysis Cell Line:LPS-stimulated RAW264.7 cell line Concentration:200 and 400 μM Incubation Time:2 hours Result:Dose-dependently decreased the mRNA levels of IL-6, TNF-α and COX-2.

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Others

Other Targets

IC50: 1.5 μM (copper-mediated LDL oxidation), 2.7 μM (AAPH-mediated LDL oxidation), 1.6 μM (SIN-1-mediated LDL oxidation)

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916888-49-8

384.38

C20H20N2O6

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years