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Laurotetanine

CAS No. 128-76-7

Laurotetanine( ——— )

Catalog No. M38575 CAS No. 128-76-7

Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Laurotetanine
  • Note
    Research use only, not for human use.
  • Brief Description
    Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways.
  • Description
    Laurotetanine is a bioactive chemical from Tetranthera & Lindera benzoin L. from family Lauraceae.
  • In Vitro
    ———
  • In Vivo
    Animal Model:Sprague Dawley (SD) rats (180-220g) Dosage:20, 40, and 60 mg/kg Administration:Oral administration; daily, for 21 days Result:Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages.Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ.Reduced serum IgE and histamine.Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    128-76-7
  • Formula Weight
    327.37
  • Molecular Formula
    C19H21NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xin XX, et, al. Anti-asthmatic effect of laurotetanine extracted from Litsea cubeba (Lour.) Pers. root on ovalbumin-induced allergic asthma rats, and elucidation of its mechanism of action. TROP J PHARM RES. 2019:18(6).
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