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Yuanhuacine
CAS No. 60195-70-2
Yuanhuacine( ——— )
Catalog No. M38396 CAS No. 60195-70-2
Yuanhuacine (Gnidilatidin), a diterpene from Daphne genkwa, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. Yuanhuacine can induce G2/M cell cycle arrest and has broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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| 50MG | Get Quote | In Stock |
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| 100MG | Get Quote | In Stock |
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Biological Information
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Product NameYuanhuacine
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NoteResearch use only, not for human use.
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Brief DescriptionYuanhuacine (Gnidilatidin), a diterpene from Daphne genkwa, is an effective and highly selective inhibitor of the basal-like 2 (BL2) subtype of TNBC. Yuanhuacine can induce G2/M cell cycle arrest and has broad anti-tumor activity. Yuanhuacine is an orally active DNA damaging agent.
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DescriptionGnidilatidin is a biochemical.
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In VitroCell Viability Assay Cell Line:H1993 cell Concentration:0, 0.00128, 0.0064, 20, 100 μM Incubation Time:24, 48, 72 h Result:Inhibited cell proliferation in a concentration- and time-dependent manner.Western Blot Analysis Cell Line:H1993 cell Concentration:0, 10, 100, 500, 1000 nM Incubation Time:24 h Result:Significantly increased p-AMPK protein levels, decreased ACC levels, inhibited the autophosphorylation of mTOR at Ser2481 site, inhibited Akt, PKC-α, Rac1 and F-actin, and activated the cell adhesion molecule E-cadherin expression.Cell Migration Assay Cell Line:H1993 cell Concentration:10, 100 nM Incubation Time:0, 24 h Result:Inhibited cell migration in a concentration-dependent manner.Cell Viability Assay Cell Line:T24T, UMUC3, HCT116 Concentration:0, 2, 4, 8, 16 μM Incubation Time:24 h Result:Inhibited cell proliferation in a dose-dependent manner.Cell Cycle Analysis Cell Line:T24T, HCT116 Concentration:2 μM Incubation Time:12 h Result:Induced significant G2/M phase arrest.Western Blot Analysis Cell Line:T24T, HCT116 Concentration:0, 1, 2 μM Incubation Time:12 h Result:Up-regulated the expression of p21 protein, but did not show observable induction of p53 protein expression and p53 protein Ser-15 phosphorylation site.
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In VivoAnimal Model:H1993 cells implanted xenograft mouse model Dosage:0.5, 1 mg/kg; daily; 21 days Administration:Oral Result:Inhibited tumor growth by 33.4% and 38.8%, respectively, reduced tumor weight, activated AMPK, and inhibited proliferation biomarkers Ki-67 and PCNA in tumor tissues.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number60195-70-2
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Formula Weight648.749
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Molecular FormulaC37H44O10
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (154.14 mM; ultraphonic)
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ji In Kang, et al. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368.?2. Ruowen Zhang, et al. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403.?3. Charles S Fermaintt, et al. Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential. Cancers (Basel). 2021 Jun 7;13(11):2834. ?
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