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Diphyllin O-glucoside
CAS No. 30021-77-3
Diphyllin O-glucoside( ——— )
Catalog No. M38350 CAS No. 30021-77-3
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameDiphyllin O-glucoside
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NoteResearch use only, not for human use.
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Brief DescriptionCleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo.
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DescriptionCleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo.
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In VitroCleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM.Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 μM.
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In VivoCleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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RecptorIC50: 6.51 μM (SARS-CoV-2)
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Research Area———
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Indication———
Chemical Information
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CAS Number30021-77-3
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Formula Weight542.488
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Molecular FormulaC27H26O12
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471.?2. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388.?3. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7.?4. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14.?
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