Albanol B

Research use only, not for human use.

Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities. Albanol B inhibits cancer cells proliferation, down-regulates CDK1 expression. Albanol B also induces cell cycle arrest at G2/M and apoptosis. And Albanol B induces mitochondrial ROS production and increases the phosphorylation levels of AKT and ERK1/2.

Albanol B is an arylbenzofuran derivative which can be isolated from mulberries. Albanol B exhibits anti-Alzheimer's disease, anti-bacterial and antioxidant activities.

Cell Viability Assay Cell Line:A549 cells, BZR, NCI-H1975, and NCI-H226 cells Concentration:0, 1, 3, 10, and 30 μM Incubation Time:48 hours Result:Exhibited inhibitory effects on cancer cells with IC50s of 5.6 μM (A549), 8.9 μM (BZR), 12.7 μM (NCI-H1975), and 15 μM (NCI-H226), respectively.Cell Cycle Analysis Cell Line:A549 and H1975 cells Concentration:1, 3, 10 μM Incubation Time:48 hours Result:Increased cells in G2/M phase from 9.5% to 14.34%, 18.13% and 47.9%, respectively.Western Blot Analysis Cell Line:A549 cells Concentration:1 h, 3 h, 6 h, and 9 h Incubation Time:48 hours Result:Increased the phosphorylation levels of ERK1/2 and AKT in time- and concentration-dependent manners.

Animal Model:EX-3LL tumor-bearing mice Dosage:50 mg/kg, 100 mg/kg Administration:IP; once daily for 21 days Result:Decreased tumor volume and weight by 48.0% and 41.0% (for 50 mg/kg treatment), and 61.3% and 57.3% (for 100 mg/kg treatment), respectively.

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Others

Other Targets

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87084-99-9

558.53

C34H22O8

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years