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LS-102
CAS No. 1456891-34-1
LS-102( ——— )
Catalog No. M38018 CAS No. 1456891-34-1
LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
|
| 5MG | 93 | In Stock |
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| 10MG | 148 | In Stock |
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| 25MG | 271 | In Stock |
|
| 50MG | 423 | In Stock |
|
| 100MG | 609 | In Stock |
|
| 200MG | 854 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLS-102
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NoteResearch use only, not for human use.
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Brief DescriptionLS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.
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DescriptionLS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor.
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In VitroCell Viability Assay Cell Line:Rheumatoid synovial cells (RSCs) m Concentration:20, 40, 60 μM Incubation Time:12 hours Result:Inhibited proliferation of RSCs with an IC50 of 5.4 μM.
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In VivoAnimal Model:7-week-old DBA/1 male mice (CIA model) Dosage:1.3, 4.0 mg/kg Administration:I.p.; daily for 4 weeks Result:Reduced the clinical severity scores.
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptor———
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Research Area———
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Indication———
Chemical Information
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CAS Number1456891-34-1
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Formula Weight452.6
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Molecular FormulaC24H36N8O
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (220.95 mM )
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yagishita N, et al. RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoidarthritis. Int J Mol Med. 2012 Dec;30(6):1281-6.?
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