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LS-102

CAS No. 1456891-34-1

LS-102( ——— )

Catalog No. M38018 CAS No. 1456891-34-1

LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 103 In Stock
5MG 93 In Stock
10MG 148 In Stock
25MG 271 In Stock
50MG 423 In Stock
100MG 609 In Stock
200MG 854 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    LS-102
  • Note
    Research use only, not for human use.
  • Brief Description
    LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.
  • Description
    LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor.
  • In Vitro
    Cell Viability Assay Cell Line:Rheumatoid synovial cells (RSCs) m Concentration:20, 40, 60 μM Incubation Time:12 hours Result:Inhibited proliferation of RSCs with an IC50 of 5.4 μM.
  • In Vivo
    Animal Model:7-week-old DBA/1 male mice (CIA model) Dosage:1.3, 4.0 mg/kg Administration:I.p.; daily for 4 weeks Result:Reduced the clinical severity scores.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    1456891-34-1
  • Formula Weight
    452.6
  • Molecular Formula
    C24H36N8O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL (220.95 mM )
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yagishita N, et al. RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoidarthritis. Int J Mol Med. 2012 Dec;30(6):1281-6.?
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