Lactic acid( —— )

Catalog No. M37801 CAS No. 50-21-5

Lactic acid (2-hydroxypropanoic acid) is a product of glycolysis and is widely found in nature.Lactic acid is produced in the body during hypoxia in contracted skeletal muscle and can be removed under fully aerobic conditions.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Lactic acid
Note

Research use only, not for human use.
Brief Description

Lactic acid (2-hydroxypropanoic acid) is a product of glycolysis and is widely found in nature.Lactic acid is produced in the body during hypoxia in contracted skeletal muscle and can be removed under fully aerobic conditions.
Description

Lactate (Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactate is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactate is an oncometabolite and has immune protective role of lactate in anti-tumor immunity.
In Vitro

Cell Proliferation Assay Cell Line:Uveal melanoma 92.1 cells Concentration:20 mM Incubation Time:24, 48 h Result:Inhibited cell proliferation and migration.Western Blot Analysis Cell Line:Uveal melanoma cells Concentration:20 mM Incubation Time:24 h Result:Showed an increase in the protein expression levels of MCT1 and HCAR1 Western Blot Analysis Cell Line:Uveal melanoma cells Concentration:20 mM Incubation Time:24 h Result:Induced a significant increase in mRNA expression levels of SLC16A1 and HCAR1.
In Vivo

Animal Model:Female C57BL/6 mice with MC38 colon cancer cells Dosage:1.6 g/kg Administration:Subcutaneous; daily from Day 8 to 30 days Result:Significantly suppressed tumor growth.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

50-21-5
Formula Weight

90.08
Molecular Formula

C3H6O3
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 100 mg/mL (1110.12 mM; Ultrasonic) DMSO : 100 mg/mL (1110.12 mM; Ultrasonic )
SMILES

CC(O)C(O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24(1):24.?

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