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5-HT3 antagonist 5
CAS No. 901599-43-7
5-HT3 antagonist 5( —— )
Catalog No. M37682 CAS No. 901599-43-7
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound that acts as a 5-HT3 receptor antagonist, counteracting 5-HT3 agonist and 2-methyl-5-HT, and demonstrating an anti-depressant effect in mice .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 65 | In Stock |
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| 25MG | 131 | In Stock |
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| 50MG | 210 | In Stock |
|
| 100MG | 300 | In Stock |
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| 200MG | 384 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name5-HT3 antagonist 5
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NoteResearch use only, not for human use.
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Brief Description5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound that acts as a 5-HT3 receptor antagonist, counteracting 5-HT3 agonist and 2-methyl-5-HT, and demonstrating an anti-depressant effect in mice .
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Description5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.
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In Vitro5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, with pA2 value of 5.
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In Vivo5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice.Animal Model:Swiss albino mice (23 ± 2 g) Dosage:1 mg/kg Administration: Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration Result:Reduced the duration of immobility as compared to the vehicle-treated (control) group.Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number901599-43-7
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Formula Weight279.29
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Molecular FormulaC16H13N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (74.58 mM; Ultrasonic (<60°C)
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SMILESCOc1ccc(NC(=O)c2cnc3ccccc3n2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mahesh R, et al. Design, synthesis and structure-activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6773-6. ?
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