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AGI-43192

CAS No. 2377491-54-6

AGI-43192( —— )

Catalog No. M37655 CAS No. 2377491-54-6

AGI-43192 is a potent methionine adenosine transferase 2A (MAT2A) inhibitor that penetrates the blood-brain barrier.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 181 In Stock
5MG 164 In Stock
10MG 263 In Stock
25MG 434 In Stock
50MG 597 In Stock
100MG 798 In Stock
200MG Get Quote In Stock
500MG 1609 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AGI-43192
  • Note
    Research use only, not for human use.
  • Brief Description
    AGI-43192 is a potent methionine adenosine transferase 2A (MAT2A) inhibitor that penetrates the blood-brain barrier.
  • Description
    AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2377491-54-6
  • Formula Weight
    484.86
  • Molecular Formula
    C23H16ClF3N6O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 13.89 mg/mL (28.65 mM; Ultrasonic (<60°C)
  • SMILES
    Cn1cc2cc(ccc2n1)-n1cc2cnc(NCC(F)(F)F)nc2c(-c2ccc(Cl)cc2)c1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615.?
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