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TGFβRI-IN-3

CAS No. 2763602-67-9

TGFβRI-IN-3( —— )

Catalog No. M37631 CAS No. 2763602-67-9

TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 187 In Stock
5MG 187 In Stock
10MG 297 In Stock
25MG 582 In Stock
50MG 888 In Stock
100MG 1274 In Stock
200MG Get Quote In Stock
500MG 2539 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    TGFβRI-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology .
  • Description
    TGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TGF-beta/Smad
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2763602-67-9
  • Formula Weight
    465.57
  • Molecular Formula
    C28H23N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (107.40 mM; Ultrasonic (<60°C)
  • SMILES
    N(C=1C2=C(C=C(C=C2)C3=CC=C(S(C)(=O)=O)C=C3)N=CC1)C=4C=C(N=CC4)C5=CC(C)=CC=C5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763.?
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