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TGFβRI-IN-3
CAS No. 2763602-67-9
TGFβRI-IN-3( —— )
Catalog No. M37631 CAS No. 2763602-67-9
TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 187 | In Stock |
|
| 5MG | 187 | In Stock |
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| 10MG | 297 | In Stock |
|
| 25MG | 582 | In Stock |
|
| 50MG | 888 | In Stock |
|
| 100MG | 1274 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2539 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTGFβRI-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionTGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology .
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DescriptionTGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTGF-beta/Smad
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Research Area——
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Indication——
Chemical Information
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CAS Number2763602-67-9
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Formula Weight465.57
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Molecular FormulaC28H23N3O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (107.40 mM; Ultrasonic (<60°C)
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SMILESN(C=1C2=C(C=C(C=C2)C3=CC=C(S(C)(=O)=O)C=C3)N=CC1)C=4C=C(N=CC4)C5=CC(C)=CC=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763.?
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