Cart
sales@molnova.com
TGFβRI-IN-3
CAS No. 2763602-67-9
TGFβRI-IN-3( —— )
Catalog No. M37631 CAS No. 2763602-67-9
TGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 187 | In Stock |
|
| 5MG | 187 | In Stock |
|
| 10MG | 297 | In Stock |
|
| 25MG | 582 | In Stock |
|
| 50MG | 888 | In Stock |
|
| 100MG | 1274 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2539 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTGFβRI-IN-3
-
NoteResearch use only, not for human use.
-
Brief DescriptionTGFβRI-IN-3 is a highly selective TGFβR1 inhibitor with an IC50 of 0.79 nM and exhibits 2000-fold selectivity against MAP4K4, showing potential applications in immuno-oncology .
-
DescriptionTGFβRI-IN-3 inhibits TGFβR1 at an IC50 of 0.79 nM with 2000-fold selectivity against MAP4K4. TGFβRI-IN-3 represents a highly selective TGFβR1 inhibitor that has potential applications in immuno-oncology.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorTGF-beta/Smad
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2763602-67-9
-
Formula Weight465.57
-
Molecular FormulaC28H23N3O2S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (107.40 mM; Ultrasonic (<60°C)
-
SMILESN(C=1C2=C(C=C(C=C2)C3=CC=C(S(C)(=O)=O)C=C3)N=CC1)C=4C=C(N=CC4)C5=CC(C)=CC=C5
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kharbanda A, et al. Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology [published online ahead of print, 2021 Aug 12]. Eur J Med Chem. 2021;225:113763.?
molnova catalog
related products
-
pep2-SVKI
Inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).
-
3-Guanidinopropionic...
3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure.?It reduces cellular ATP creatine and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK) activating PPARγ coactivator 1α (PGC-1α).
-
Kauniolide
Kauniolide(81066-45-7) is a natural compound.
