Cart
sales@molnova.com
UNC8153 TFA
CAS No. 2929304-61-8
UNC8153 TFA( —— )
Catalog No. M37355 CAS No. 2929304-61-8
UNC8153 TFA is a selective and potent NSD2 protein degrader with anticancer activity.UNC8153 TFA induces NSD2 degradation in MM.1S multiple myeloma cells and inhibits the proliferation of MM.1S cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 234 | In Stock |
|
| 5MG | 150 | In Stock |
|
| 10MG | 236 | In Stock |
|
| 25MG | 377 | In Stock |
|
| 50MG | 529 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameUNC8153 TFA
-
NoteResearch use only, not for human use.
-
Brief DescriptionUNC8153 TFA is a selective and potent NSD2 protein degrader with anticancer activity.UNC8153 TFA induces NSD2 degradation in MM.1S multiple myeloma cells and inhibits the proliferation of MM.1S cells.
-
DescriptionUNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorHistone Methyltransferase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2929304-61-8
-
Formula Weight697.7
-
Molecular FormulaC35H38F3N5O7
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(O)C(F)(F)F.O=C(NC1=CC=C(C=C1)C(=O)NCCCCCCN)C2=CC=C(C=C2)CN(C(=O)C3=CC=C4NC(=O)COC4=C3)C5CC5
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188. ?
molnova catalog
related products
-
Dendroaspis Natriure...
Dendroaspis Natriuretic Peptide is a vasodilator peptide that can be isolated from animal venom.
-
GSK2033
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
-
4-Methoxycinnamaldeh...
4-Methoxycinnamaldehyde is an active ingredient of Agastache rugosa.4-Methoxycinnamaldehyde has cytoprotective activity against respiratory syncytial virus (RSV) in human laryngeal carcinoma cell lines, and helps to control disease induced by RSV infection, with an IC50 of approximately 0.055 μg/mL. The IC50 was about 0.055 μg/mL.
