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Anti-inflammatory agent 49
CAS No. 851471-44-8
Anti-inflammatory agent 49( —— )
Catalog No. M37317 CAS No. 851471-44-8
Anti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction, inhibits GTPase, and can be used in the study of diseases caused by mitochondrial dysfunction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 202 | In Stock |
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| 10MG | 330 | In Stock |
|
| 25MG | 660 | In Stock |
|
| 50MG | 1014 | In Stock |
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| 100MG | 1376 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAnti-inflammatory agent 49
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NoteResearch use only, not for human use.
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Brief DescriptionAnti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction, inhibits GTPase, and can be used in the study of diseases caused by mitochondrial dysfunction.
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Descriptionnti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM.
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In VitroCell Viability Assay Cell Line:H9c2 cells Concentration:2 μM Incubation Time:16?h Result:Decreased the percentage of cells with fragmented mitochondria. The percent of fragmented cells was decreased from 22% (LPS + Veh) to 9% (LPS + SC9), relative to 4% in the absence of LPS.Western Blot Analysis Cell Line:H9c2 cells Concentration:2 μM Incubation Time:24?h Result:Decreased the number of high Drp1-Fis1 cells from 67% (LPS + Veh) to 28% (LPS + P110) and to 14% (LPS + SC9).
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In VivoAnimal Model:Female BALB/c AnNCrl micee (Strain Code 028)Dosage:LPS doses 10–16.67 mg/kg, SC9 doses 10 mg/kg(after 4 h) Administration:Intraperitoneal injection: 0.2 mL of LPS,0.1 mL of CS9; scored every 8 h for 72 h.Result:Improved mouse survival at all LPS doses tested at the different LPS doses (10 to 16.6 mg/kg) .Dramatically reduced the occurrence of critical symptoms such as respiratory distress.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGTPase
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Research Area——
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Indication——
Chemical Information
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CAS Number851471-44-8
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Formula Weight466.52
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Molecular FormulaC21H22N8O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC(=O)N(C(N)=C1N(C(=O)CSC=2N=C3N=C(C=C(N3N2)C)C)C)CC=4C=CC=CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Luis Rios, et al. Targeting an allosteric site in dynaminrelated protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14(1):4356?
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