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Rezatapopt

CAS No. 2636846-41-6

Rezatapopt( —— )

Catalog No. M37295 CAS No. 2636846-41-6

Rezatapopt (PC14586) is a small molecule p53 reactivator with anti-tumor activity that selectively binds to the cleft present in the TP53 Y220C mutant protein and restores the p53 wild-type (normal) conformation and transcriptional activity, and can be used to study locally advanced or metastatic solid tumors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rezatapopt
  • Note
    Research use only, not for human use.
  • Brief Description
    Rezatapopt (PC14586) is a small molecule p53 reactivator with anti-tumor activity that selectively binds to the cleft present in the TP53 Y220C mutant protein and restores the p53 wild-type (normal) conformation and transcriptional activity, and can be used to study locally advanced or metastatic solid tumors.
  • Description
    Rezatapopt is an antineoplastic agent, used to inhibit solid tumor with p53 mutation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    p53
  • Recptor
    p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2636846-41-6
  • Formula Weight
    545.57
  • Molecular Formula
    C28H31F4N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C1=C2C(N(CC(F)(F)F)C(C#CCNC3=C(OC)C=C(C(NC)=O)C=C3)=C2)=CC=C1)[C@H]4[C@@H](F)CN(C)CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li Sujing, et al. Heteroarylalkyne compounds for targeting mutant of p53 and their preparation. World Intellectual Property Organization, WO2023016434 A1. 2023-02-16.
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