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TIM-3-IN-2
CAS No. 1113126-49-0
TIM-3-IN-2( —— )
Catalog No. M37234 CAS No. 1113126-49-0
TIM-3-IN-2 is a Tim3 inhibitor that inhibits the binding of TIM-3 to PtdSer, CEACAM1, and Gal-9 and inhibits the action of TIM-3.TIM-3-IN-2 is able to reverse TIM-3-mediated pro-inflammatory cytokine action.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTIM-3-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionTIM-3-IN-2 is a Tim3 inhibitor that inhibits the binding of TIM-3 to PtdSer, CEACAM1, and Gal-9 and inhibits the action of TIM-3.TIM-3-IN-2 is able to reverse TIM-3-mediated pro-inflammatory cytokine action.
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DescriptionTIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (KD: 0.61 μM). TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorImmunology/Inflammation related
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Research Area——
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Indication——
Chemical Information
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CAS Number1113126-49-0
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Formula Weight461.47
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Molecular FormulaC25H23N3O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (216.70 mM; Ultrasonic )
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SMILESO=C(NC1=CC=C(OC)C=C1OC)COC2=CC=CC(=C2)C3=NC(=NO3)C=4C=CC(OC)=CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Orexin A (human, rat...
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6-TAMRA-SE
6-TAMRA-SE is an amine-reactive form of tetramethylrhodamine and one of the traditional fluorophores used for automated DNA sequencing.
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Trometamol hydrochlo...
Trometamol hydrochloride (Tromethamine hydrochloride) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo.
