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PD-L1-IN-3

CAS No. 2953044-29-4

PD-L1-IN-3( —— )

Catalog No. M37233 CAS No. 2953044-29-4

PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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25MG	655	In Stock
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Biological Information

Product Name

PD-L1-IN-3
Note

Research use only, not for human use.
Brief Description

PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation.
Description

PD-L1-IN-3 (Compound 4a) functions as an inhibitor of the PD-1/PD-L1 axis, with an IC50 value of 4.97 nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1 interaction by binding to the PD-L1 dimer, obstructing PD-1 signaling. This compound is utilized in research pertaining to lung cancer and melanoma .
In Vitro

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In Vivo

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Synonyms

——
Pathway

Immunology/Inflammation
Target

PD-1/PD-L1
Recptor

PD-1/PD-L1
Research Area

——
Indication

——

Chemical Information

CAS Number

2953044-29-4
Formula Weight

373.85
Molecular Formula

C19H15ClFN2OS
Purity

>98% (HPLC)
Solubility

——
SMILES

[Cl].N#CC1=C(OCC2=CC=C(C=C2)CN)SC=C1C=3C=CC(F)=CC3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

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