Nrf2 activator-3

Research use only, not for human use.

Nrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant, and anti-tumor activities, suitable for studying neurological and immune-related diseases.

Nrf2 activator-3 is a potent Nrf2 activator. Nrf2 activator-3 is used for cerebral ischemic injury research.

Cell Viability Assay Cell Line:PC12 cell Concentration:1 μM, 5 μM, and 10 μM Incubation Time:Result:Alleviated SNP-induced apoptosis in a concentration-dependent manner.

Animal Model:MCAO rats Dosage:3 mg/kg; 10 mg/kg; 30 mg/kg Administration:Intraperitoneal injection Result:Attenuated cerebral ischemic injury.(low dose: 16.37 ± 6.51%, medium dose: 14.49 ± 5.62%, high dose: 12.23 ± 8.50%), which was similar to the effect of Edaravone (12.77 ± 5.82%).Animal Model:MCAO rats Dosage:3 mg/kg; 10 mg/kg; 30 mg/kg Administration:Intraperitoneal injection Result:Attenuated cerebral ischemic injury.(low dose: 16.37 ± 6.51%, medium dose: 14.49 ± 5.62%, high dose: 12.23 ± 8.50%), which was similar to the effect of Edaravone (12.77 ± 5.82%).

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Others

Antioxidant

Antioxidant | Nrf2

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2766570-23-2

425.4

C23H18F3N3O2

>98% (HPLC)

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FC(F)(F)C=1C=CC(=C(O)C1)C=2N=C(C=3C=CC=CC3O)N(N2)C=4C=C(C=C(C4)C)C

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(-20℃)

With Ice Pack

≥ 2 years