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P-gb-IN-1
CAS No. 2632874-49-6
P-gb-IN-1( —— )
Catalog No. M36962 CAS No. 2632874-49-6
P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydrogen bonding with residues Asn 721 and Met 986. P-gb-IN-1 showed low toxicity in MCF-7/ADR cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 193 | In Stock |
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| 10MG | 276 | In Stock |
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| 25MG | 430 | In Stock |
|
| 50MG | 581 | In Stock |
|
| 100MG | 768 | In Stock |
|
| 200MG | 1032 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameP-gb-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionP-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydrogen bonding with residues Asn 721 and Met 986. P-gb-IN-1 showed low toxicity in MCF-7/ADR cells.
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DescriptionP-gb-IN-1 (compound Ⅲ-8), a 2,5-disubstituted furan derivative, is a highly effective, broadspectrum P-glycoprotein (P-gp) inhibitor. P-gb-IN-1 displayed the reversal activity by inhibiting P-gp efflux. P-gb-IN-1 has a potent affinity to P-gp by forming H-bond interactions with residues Asn 721 and Met 986. P-gb-IN-1 possesses broad-spectrum reversal activity and low toxicity in MCF-7/ADR cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorP-gp
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Research Area——
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Indication——
Chemical Information
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CAS Number2632874-49-6
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Formula Weight512.55
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Molecular FormulaC30H28N2O6
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC=1C=CC(=CC1)C=2OC(=CC2)C(=O)N3CC4=CC(OC)=C(OC)C=C4CC3)C5=CC=C(OC)C=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhikun Yang, et al. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell. Eur J Med Chem. 2023 Sep 5;257:115462.?
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