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Inbakicept
CAS No. 2135939-52-3
Inbakicept( —— )
Catalog No. M36799 CAS No. 2135939-52-3
Inbakicept (ALT 803) is a fusion protein of the IL-15 receptor α-sushi binding domain IL-15RαSu and immunoglobulin G1 (human Fc fragment), which is an IL-15 superagonist protein complex.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameInbakicept
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NoteResearch use only, not for human use.
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Brief DescriptionInbakicept (ALT 803) is a fusion protein of the IL-15 receptor α-sushi binding domain IL-15RαSu and immunoglobulin G1 (human Fc fragment), which is an IL-15 superagonist protein complex.
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DescriptionInbakicept, also known as N-803 (Nogapendekin alfa inbakicept), contains the IL-15 cytokine antibody Nogapendekin alfa (HY-P99759). Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). Inbakicept also increases degranulation and IFNγ production in cells.
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In VitroCell Cytotoxicity Assay Cell Line:Daudi, Raji, CD19+ FL cells Concentration:0.01 nM, 0.1 nM, and 1 nM Incubation Time:20 hours Result:Increased the human NK cell cytotoxicity on Daudi, Raji, CD19+ FL cells.
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In VivoAnimal Model:SCID mice with Daudi models Dosage:0.02 mg/kg, 0.05 mg/kg, 0.1 mg/kg, and 0.2 mg/kg Administration:Intravenous injection; twice weekly, for 2 weeks Result:Enhanced rituximab-directed control of Raji lymphoma challenge.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2135939-52-3
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rosario M, et al. The IL-15-Based ALT-803 Complex Enhances FcγRIIIa-Triggered NK Cell Responses and In Vivo Clearance of B Cell Lymphomas. Clin Cancer Res. 2016 Feb 1;22(3):596-608. ?
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