I-152( —— )

Catalog No. M36625 CAS No. 311343-11-0

I-152, a conjugate of N-acetyl-cysteine (NAC) and cysteamine (MEA), activates NRF2 and ATF4 signaling pathways and exhibits anti-proliferative properties .

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

I-152
Note

Research use only, not for human use.
Brief Description

I-152, a conjugate of N-acetyl-cysteine (NAC) and cysteamine (MEA), activates NRF2 and ATF4 signaling pathways and exhibits anti-proliferative properties .
Description

I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties.
In Vitro

Western Blot Analysis Cell Line:RAW 264.7 cells.Concentration:0.062, 0.125, 0.25, 1, 5 or 10 mM.Incubation Time:2 h or 24 h.Result:Reduced the expression of NRF2/β-ACTIN, increased the expression of GCLM.
In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

311343-11-0
Formula Weight

264.36
Molecular Formula

C9H16N2O3S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (378.27 mM; Ultrasonic )
SMILES

[C@H](C(NCCSC(C)=O)=O)(NC(C)=O)CS
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Crinelli R, et al. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel). 2021 Jan 26;10(2):175. ?

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