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I-152

CAS No. 311343-11-0

I-152( —— )

Catalog No. M36625 CAS No. 311343-11-0

I-152, a conjugate of N-acetyl-cysteine (NAC) and cysteamine (MEA), activates NRF2 and ATF4 signaling pathways and exhibits anti-proliferative properties .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    I-152
  • Note
    Research use only, not for human use.
  • Brief Description
    I-152, a conjugate of N-acetyl-cysteine (NAC) and cysteamine (MEA), activates NRF2 and ATF4 signaling pathways and exhibits anti-proliferative properties .
  • Description
    I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties.
  • In Vitro
    Western Blot Analysis Cell Line:RAW 264.7 cells.Concentration:0.062, 0.125, 0.25, 1, 5 or 10 mM.Incubation Time:2 h or 24 h.Result:Reduced the expression of NRF2/β-ACTIN, increased the expression of GCLM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    311343-11-0
  • Formula Weight
    264.36
  • Molecular Formula
    C9H16N2O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (378.27 mM; Ultrasonic )
  • SMILES
    [C@H](C(NCCSC(C)=O)=O)(NC(C)=O)CS
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Crinelli R, et al. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel). 2021 Jan 26;10(2):175. ?
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