USP28-IN-4( —— )

Catalog No. M36612 CAS No. 2931509-15-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

USP28-IN-4
Note

Research use only, not for human use.
Brief Description

USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5.
Description

USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331).
In Vitro

Western Blot Analysis Cell Line:Human colorectal cancer cells HCT116 and Ls174T Concentration:20 μM, 30 μM, 50 μM, and 60 μM, for Ls174T; 30 μM, 50 μM, 60 μM and 80 μM for HCT116 Incubation Time:24 h Result:Dose-dependently down-regulated the cellular level of c-Myc.
In Vivo

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Synonyms

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Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

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Indication

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1. Zhou D, et al. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. Eur J Med Chem. 2023 Jun 5;254:115369.?

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