Smurf1-IN-A01 is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM).

Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG.

Valeroyl Salicylate is a non-steroidal anti-inflammatory agent and can lead to extension of lifespan, delays age-dependent decline of locomotor activity, and increases stress resistance.