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MAHMA NONOate
CAS No. 146724-86-9
MAHMA NONOate( —— )
Catalog No. M36577 CAS No. 146724-86-9
MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMAHMA NONOate
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NoteResearch use only, not for human use.
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Brief DescriptionMAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
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DescriptionMAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.
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In VitroMAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP.MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively.
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In VivoMAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo.Animal Model:Male Wistar rats anaesthetised with pentobarbitone Dosage:0.3-10 nmol/kg/min Administration:Intravenous injection; 0.3-10 nmol/kg/min once Result:Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorEndogenous Metabolite | NO Synthase
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Research Area——
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Indication——
Chemical Information
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CAS Number146724-86-9
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Formula Weight204.27
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Molecular FormulaC8H20N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 62.5 mg/mL (305.97 mM; adjust pH to 10 with NaOH)
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SMILESO=NN(O)N(C)CCCCCCNC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Homer KL, Wanstall JC. Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate. Br J Pharmacol. 2002 Dec;137(7):1071-81.?
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