Cart
sales@molnova.com
Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - MAHMA NONOate

MAHMA NONOate

CAS No. 146724-86-9

MAHMA NONOate( —— )

Catalog No. M36577 CAS No. 146724-86-9

MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    MAHMA NONOate
  • Note
    Research use only, not for human use.
  • Brief Description
    MAHMA NONOate is a pH-dependent NO donor.MAHMA NONOate inhibits collagen or ADP-induced platelet aggregation.
  • Description
    MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.
  • In Vitro
    MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP.MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively.
  • In Vivo
    MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo.Animal Model:Male Wistar rats anaesthetised with pentobarbitone Dosage:0.3-10 nmol/kg/min Administration:Intravenous injection; 0.3-10 nmol/kg/min once Result:Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Endogenous Metabolite | NO Synthase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    146724-86-9
  • Formula Weight
    204.27
  • Molecular Formula
    C8H20N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 62.5 mg/mL (305.97 mM; adjust pH to 10 with NaOH)
  • SMILES
    O=NN(O)N(C)CCCCCCNC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Homer KL, Wanstall JC. Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate. Br J Pharmacol. 2002 Dec;137(7):1071-81.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Cyclo(his-pro)

    Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.?

  • 6-Methylnicotinamide

    6-Methylnicotinamide is a derivative of nicotinamide, an endogenous metabolite. 6-Methylnicotinamide is used to make co-crystals/salts.

  • Phosphorylcholine B

    Phosphorylcholine is widely present in the biological world, which is a phospholipid present in the eukaryotic biofilm, and also in the symbiotic bacteria or pathogens associated with eukaryotes.

Sign In Join Free