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TH-Z93

CAS No. 2260887-09-8

TH-Z93( —— )

Catalog No. M36537 CAS No. 2260887-09-8

TH-Z93 is a potent FPPS inhibitor (IC50:90 nM) and a lipophilic bisphosphonate.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TH-Z93
  • Note
    Research use only, not for human use.
  • Brief Description
    TH-Z93 is a potent FPPS inhibitor (IC50:90 nM) and a lipophilic bisphosphonate.
  • Description
    TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM).
  • In Vitro
    ——
  • In Vivo
    TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model.Animal Model:B16-OVA cells (s.c.) xenograft mice model.Dosage:20 μg Administration:Intraperitoneal injection (i.p.)Result:Inhibited tumor growth and prolonged survival.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2260887-09-8
  • Formula Weight
    368.26
  • Molecular Formula
    C12H22N2O7P2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 1.89 mg/mL (5.13 mM; ultrasonic and warming and adjust pH to 10 with NaOH and heat to 60°C)
  • SMILES
    C(NC1=CC(OCCCCCC)=CC=N1)(P(=O)(O)O)P(=O)(O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. ?
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