TH-Z93( —— )

Catalog No. M36537 CAS No. 2260887-09-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

TH-Z93
Note

Research use only, not for human use.
Brief Description

TH-Z93 is a potent FPPS inhibitor (IC50:90 nM) and a lipophilic bisphosphonate.
Description

TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM).
In Vitro

——
In Vivo

TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model.Animal Model:B16-OVA cells (s.c.) xenograft mice model.Dosage:20 μg Administration:Intraperitoneal injection (i.p.)Result:Inhibited tumor growth and prolonged survival.
Synonyms

——
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

——
Indication

——

CAS Number

2260887-09-8
Formula Weight

368.26
Molecular Formula

C12H22N2O7P2
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 1.89 mg/mL (5.13 mM; ultrasonic and warming and adjust pH to 10 with NaOH and heat to 60°C)
SMILES

C(NC1=CC(OCCCCCC)=CC=N1)(P(=O)(O)O)P(=O)(O)O
Chemical Name

——

1. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. ?

Calculator

molnova catalog