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TNG908
CAS No. 2760481-53-4
TNG908( —— )
Catalog No. M36534 CAS No. 2760481-53-4
TNG908 is an orally active and selective MTAP-co-PRMT5 inhibitor that crosses the blood-brain barrier and kills MTAP-deficient cancers.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 161 | In Stock |
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| 5MG | 148 | In Stock |
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| 10MG | 236 | In Stock |
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| 25MG | 377 | In Stock |
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| 50MG | 529 | In Stock |
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| 100MG | 731 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTNG908
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NoteResearch use only, not for human use.
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Brief DescriptionTNG908 is an orally active and selective MTAP-co-PRMT5 inhibitor that crosses the blood-brain barrier and kills MTAP-deficient cancers.
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DescriptionTNG908 is a MTAP-cooperative PRMT5 inhibitor that can pass through the blood-brain barrier. TNG908 is 15 times more selective for MTAP null cell lines than MTAPWT cell lines, and can be used in cancer research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorHistone Methyltransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number2760481-53-4
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Formula Weight409.51
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Molecular FormulaC21H23N5O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (244.20 mM; Ultrasonic )
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SMILESC(C(NC=1C=C(C)C(N)=NC1)=O)(=O)N2[C@H](CC[C@H](C)C2)C=3C=C4C(=CC3)SC=N4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. K. Briggs, et al. TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted cancer.MOLECULAR TARGETED AGENTS 2
?VOLUME 174, SUPPLEMENT 1,?S84,?OCTOBER 2022.
?VOLUME 174, SUPPLEMENT 1,?S84,?OCTOBER 2022.
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