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Miclxin
CAS No. 2494198-61-5
Miclxin( —— )
Catalog No. M36523 CAS No. 2494198-61-5
Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 150 | In Stock |
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| 5MG | 136 | In Stock |
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| 10MG | 192 | In Stock |
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| 25MG | 324 | In Stock |
|
| 50MG | 442 | In Stock |
|
| 100MG | 607 | In Stock |
|
| 200MG | 817 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMiclxin
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NoteResearch use only, not for human use.
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Brief DescriptionMiclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.
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DescriptionMiclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex.
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In VitroCell Viability Assay Cell Line:HCT116 (CTNNB1 +/–) and (CTNNB1 △45/–)Concentration:0, 5, 8, 10, 12, and 15 μM Incubation Time:48 hours Result:Inhibited cell growth with inhibition rate of 100% at 15 μM.
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In Vivo——
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorWnt/beta-catenin
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Research Area——
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Indication——
Chemical Information
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CAS Number2494198-61-5
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Formula Weight441.52
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Molecular FormulaC26H27N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (22.65 mM; Ultrasonic (<80°C)
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SMILESN(CC1=CC(OC)=CC=C1)C=2C3=C(N=C(N2)N4CC(CC4)C=5C=CC=NC5)C=C(OC)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204. ?
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