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PRMT6-IN-3
CAS No. 2890765-10-1
PRMT6-IN-3( —— )
Catalog No. M36506 CAS No. 2890765-10-1
PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 107 | In Stock |
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| 10MG | 163 | In Stock |
|
| 25MG | 282 | In Stock |
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| 50MG | 423 | In Stock |
|
| 100MG | 592 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePRMT6-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionPRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.
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DescriptionPRMT6-IN-3 (compound 25) is a selective PRMT6 inhibitor with an IC50 value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity.
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In VitroPRMT6-IN-3(compound 25) (80 μM, 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells. PRMT6-IN-3(compound 25) (0-40 μM, 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorHistone Methyltransferase | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number2890765-10-1
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Formula Weight374.5
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Molecular FormulaC19H26N4O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESC(N(CCNC)C)C1=CC(=CN=C1)C2=CC=C(NS(=O)(=O)C3CC3)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Qiangsheng Zhang, et al. Design, synthesis and evaluation of antitumor activity of selective PRMT6 inhibitors. Eur J Med Chem. 2022 Dec 20;247:115032.?
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