Clozapine N-oxide dihydrochloride( —— )

Catalog No. M36444 CAS No. 2250025-93-3

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Product Name

Clozapine N-oxide dihydrochloride
Note

Research use only, not for human use.
Brief Description

Clozapine N-oxide dihydrochloride, a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs), crosses the blood-brain barrier and activates DREADD receptors hM3Dq and hM4Di.
Description

Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
In Vitro

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In Vivo

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Synonyms

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Pathway

Metabolic Enzyme/Protease
Target

AChE
Recptor

AChE
Research Area

——
Indication

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CAS Number

2250025-93-3
Formula Weight

452.2
Molecular Formula

C18H22Cl4N4O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 240 mg/mL (577.28 mM; Ultrasonic ) H2O : 100 mg/mL (240.53 mM; Ultrasonic)
SMILES

C[N+]1([O-])CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=C2C=CC=C4.Cl.Cl.Cl
Chemical Name

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1. Wess J, et al. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92.?

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